Peptides
Cortagen
Also called Cortagen
Cortagen is explored for nerve recovery, memory and clearer thinking. Its most concrete recovery signal comes from an injured-nerve experiment in rats—not a demonstrated treatment for human neuropathy or brain fog. A cortex-focused name does not mean it selectively repairs whichever neurological problem someone has.
Dosage & duration
Animal research context only
Rat sciatic-nerve experiment
Published example · product-specific- Dose
- 10 mcg/kg in rats
- How often
- Once daily, intramuscular
- How long
- 10 days after experimental nerve injury
This is an animal protocol, not a human amount or a dose to scale by body weight.
Sources: 1
Live research found incompatible human schedules and a guide with arithmetic errors; no dependable common dose or cycle can be inferred from them.
The practical difference
Nerve recovery or clearer thinking?
Cortagen attracts interest for both, but they are different outcomes.
| Context | Nerve recovery | Clearer thinking |
|---|---|---|
| The goal | Regaining useful function after injury | Better attention and recall in everyday life |
| Cited experiment | A surgically repaired sciatic nerve in rats | Did not test everyday attention or memory |
Why is it discussed for nerves?
An early rat experiment reported improvements in regeneration measures after a sciatic nerve was cut and repaired. That is more specific than a vague brain-regeneration claim, but very different from treating diabetic neuropathy, spinal injury or memory problems in people.
What about focus and brain fog?
Those are frequent nootropic goals, but gene-expression findings and animal movement tests do not establish better attention or recall. Increased activity is not automatically improved cognition.
Why not combine the online dose ranges?
The reviewed guides range widely and sometimes contain inconsistent vial math. Combining them would create a new unsupported regimen. We show the original animal context while keeping a human course explicitly unresolved.
A useful next step
Describe the deficit clearly: pain, weakness, sensation, balance or memory. New weakness, progressive numbness or a sudden neurological change should not be managed as a peptide experiment. Rehabilitation and diagnostic care remain distinct from supplement tracking.
Model details: Cortagen · relative timing
Compare timing and buildup for this compound. The values are not blood concentrations or a measure of strength.
Shows a relative timing scenario; absolute blood concentrations are not calibrated.
Timing assumptions and sources
Legacy 4.08 h is unverified; five consecutive treatment days do not imply any particular half-life.
One 1 mg input peaks at 1 relative unit after a single dose. Other amounts scale proportionally; overlapping doses add when accumulation is on. Different compounds use separate relative scales.
- Timing half-life used
- 4.08 hours
- Absorption half-life assumed
- 1.02 hours
- Reference amount for the relative scale
- 1 mg
- Absorption half-life is assumed to be one quarter of the slower timescale (1.02 h); it is not a measured absorption parameter.
- A single 1-unit input has a peak of 1 relative unit; scaling and repeated-dose addition are mathematical assumptions. This normalization is independent of the example dose.
- Cortagen tetrapeptide is not Cortexin brain extract.
- Clinical-effect assertions in an introduction are not concentration measurements.
- Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.
Legacy 4.08 h is unverified; five consecutive treatment days do not imply any particular half-life.
cortagen-relative-timing-2026-10 · version 1
Common questions
Does Cortagen regrow human nerves?
The cited injured-nerve result is from rats. It does not establish functional human nerve regrowth or a treatment course.
Is it the same as Cortexin?
A similar brain-related name does not establish the same product. Cortagen is a defined short peptide; another preparation’s amount or evidence should not be transferred by name.
Sources Labels, studies and notes behind this guide
Catalog evidence: Animal or laboratory research. This describes the type of evidence, not a clinical review of every claim.
Summary and fact source checks: 2026-10-07. This records source checking, not medical review of the whole page.
Notes on the quick facts
- Main interests
- These are different clinical problems, not one brain-support outcome.
- Best recovery signal
- It does not establish human nerve regrowth.
- Dose claims
- Online microgram and milligram schedules are inconsistent.
- 1. Turchaninova et al.: Cortagen and rat sciatic nerve
Original paper text inspected: rat nerve transection/suture,10 mcg/kg IM daily for 10 days; not a human protocol.
- 2. Cortagen public dosing guide
Guide inspected through indexed full excerpt; claims a200 mcg course but has conflicting reconstitution arithmetic. Not adopted as a reliable human regimen.
- 3. Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.
Legacy 4.08 h is unverified; five consecutive treatment days do not imply any particular half-life.
- 4. Khavinson et al. 2004 — Cortagen gene expression
Ala-Glu-Asp-Pro identity; five-day mouse experiment measured heart gene expression, not human cognition or nerve regrowth.
- 5. Tissue-specific peptide effects, 2001
Rat organotypic explants, including brain-cortex response to Cortagen; preclinical preparation context.
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