Methodology
This page explains how PeptidePlotter estimates blood concentration curves so you can interpret every chart with appropriate skepticism.
The 3-tier (plus inherited) PK model
Each compound in our dataset is assigned one of four model tiers based on the quality of published pharmacokinetic data. We use a one-compartment model with first-order absorption (the Bateman function) and superpose individual doses to simulate accumulation.
Advanced model
Inputs: t½ + Cmax + Tmax + F%
Used when all four pharmacokinetic parameters are known. Produces the most accurate concentration curve in real units.
Examples: Testosterone Propionate, Testosterone Undecanoate (Castor Oil), Testosterone Undecanoate (MCT Oil), Testosterone Undecanoate (Oral), Testosterone Suspension, Testosterone Gel (Testogel/AndroGel)…
Linear regression model
Inputs: slope + intercept
For compounds whose peak concentration does not scale linearly with dose (e.g. testosterone esters). Dose-scaling is sublinear.
Examples: Testosterone Enanthate, Testosterone Cypionate
Simple model
Inputs: t½ + F% (Tmax estimated)
Fallback when only half-life and bioavailability are published. Tmax is estimated from the half-life.
Examples: Testosterone Phenylpropionate, Testosterone Isocaproate, Testosterone Decanoate, Estradiol Valerate, Trenbolone Enanthate, Trenbolone Acetate…
Inherited model
Inputs: parent compound model
When no human data exists, the model is inherited from a structurally similar compound. Treat results as approximate.
Examples: Boldenone Cypionate
Limitations
- Simplified model. One-compartment, first-order kinetics ignore distribution phases, protein binding saturation, and active metabolites.
- Individual variation. Real levels vary widely with genetics, body composition, and organ function. Use the per-compound "Adjust levels" slider to explore sensitivity.
- Not medical advice. These curves are for research and harm-reduction education. They will not precisely predict any individual's blood levels.
Data sources
Our compound dataset is derived from a competitor's public pharmacokinetics spreadsheet, cross-referenced to primary literature. Every compound page links to its source. 150 compounds are currently indexed across 1 categories.