Peptides
Sermorelin
Also called GRF 1-29
Adults usually encounter sermorelin through clinics promoting sleep, recovery and body composition. It stimulates the body’s growth-hormone release rather than supplying HGH directly, but the older Geref approval does not prove today’s adult anti-aging claims.
Dosage & duration
One adult clinic’s published practice; not a universal or approved anti-aging regimen.
Renew clinic handout example
Reported use · unapproved regimen- Dose
- 100–300 mcg per injection
- How often
- Under the skin before bed, five nights weekly
- How long
- 3–6 months; reassessment every 90 days
A published adult wellness example, not a validated anti-aging course or a regimen supported by the historical pediatric approval.
Sources: 1
Historical pediatric or diagnostic dosing should not be converted into an adult wellness dose.
Beyond a lab result
Judge sleep and recovery separately
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Sleep quality
The goal is better sleep and next-day function.
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Training recovery
The goal is feeling ready for normal activity and training.
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Blood markers
A higher IGF-1 result alone does not establish either benefit.
Why people choose it over HGH
The attraction is prompting the pituitary to release growth hormone instead of injecting the hormone itself. That mechanism does not guarantee better sleep, more muscle or fewer side effects. A low-energy or poor-recovery complaint can have causes unrelated to GH.
What a clinic dose actually represents
Published adult clinic schedules are off-label practice examples. They are not the old childhood-growth indication or the intravenous GH stimulation test. The handout’s three-month review point is a clinic follow-up schedule, not proof that benefits require exactly that length.
How to judge results
Separate a rise in IGF-1 from a meaningful change in sleep, recovery or daily function. Formulation, medical history and follow-up matter; a bedtime curve alone cannot confirm that treatment is helping.
Model details: Sermorelin · relative timing
Compare timing and buildup for this compound. The values are not blood concentrations or a measure of strength.
Shows a relative timing scenario; absolute blood concentrations are not calibrated.
Timing assumptions and sources
Soule1994 human IV disappearance half-time4.3±1.4min; using it for SC is a route extrapolation, not a measured SC terminal value.
One 1 mg input peaks at 1 relative unit after a single dose. Other amounts scale proportionally; overlapping doses add when accumulation is on. Different compounds use separate relative scales.
- Timing half-life used
- 0.07166667 hours
- Absorption half-life assumed
- 0.01791667 hours
- Reference amount for the relative scale
- 1 mg
- Absorption half-life is assumed to be one quarter of the slower timescale (0.017916666666666668 h); it is not a measured absorption parameter.
- A single 1-unit input has a peak of 1 relative unit; scaling and repeated-dose addition are mathematical assumptions. This normalization is independent of the example dose.
- Historical Geref11–12min and6%SC figures were located only via secondary mirrors, not a primary label; not silently adopted.
- No matched SC concentration endpoint set recovered; do not borrow GH peaks.
- Soule et al.1994 GHRH(1–29)-NH2 disposition
10 normal men;25ng/kg/min IV90min. GHRH1–29 half-time4.3min,MCR39.7mL/kg/min. D-Ala2 comparator6.7min is not sermorelin.
- Wilton et al.1993 GHRH1–29 IV/intranasal study
30 healthy men;IV and intranasal, nasalF3–5%; GH response lasted~3h, not drug terminal half-life.
sermorelin-relative-timing-2026-10 · version 1
Common questions
Is sermorelin the same as HGH?
No. Sermorelin stimulates growth-hormone release; HGH products supply the hormone directly.
Does the old approval prove it works for anti-aging?
No. The former Geref indication and diagnostic use do not establish those adult wellness claims.
Sources Labels, studies and notes behind this guide
Catalog evidence: Other human research. This describes the type of evidence, not a clinical review of every claim.
Summary and fact source checks: 2026-10-07. This records source checking, not medical review of the whole page.
Notes on the quick facts
- Common goals
- Clinic-marketed goals with limited direct adult outcome evidence.
- Different from HGH
- Does not directly supply the full hormone.
- Approval context
- Not an adult anti-aging endorsement.
- 1. Renew — sermorelin client information and dosing guideline
Original four-page clinic handout opened 7 Oct 2026. Pages 1–2 describe 100–300 mcg SC before bed, five nights/week, a 3–6 month course and reassessment every 90 days. Named practice example only. Later syringe arithmetic is inconsistent and not used; efficacy, safety, receptor-reset and storage claims are not adopted.
- 2. FDA Geref determination
Original therapeutic indication was childhood GH deficiency; separate diagnostic presentation. Withdrawal not for safety/effectiveness reasons does not create an adult anti-aging approval.
- 3. HPRA Geref product information
Diagnostic intravenous product; demonstrates product/route distinction, not adult bedtime treatment evidence.
- 4. Soule et al.1994 GHRH(1–29)-NH2 disposition
10 normal men;25ng/kg/min IV90min. GHRH1–29 half-time4.3min,MCR39.7mL/kg/min. D-Ala2 comparator6.7min is not sermorelin.
- 5. Wilton et al.1993 GHRH1–29 IV/intranasal study
30 healthy men;IV and intranasal, nasalF3–5%; GH response lasted~3h, not drug terminal half-life.
- 6. FDA GEREF withdrawal determination, 2013
Pages 14095–14096: historical diagnostic/pediatric approvals, discontinued products and finding that withdrawal was not for safety/effectiveness reasons.
- 7. Soule et al.: GHRH(1–29) clearance in men
Original human study reports short IV disappearance half-time; D-Ala2 analogue is a separate molecule, not generic sermorelin.
Keep reading
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CJC-1295 with DAC appeals to people seeking longer-lasting GH stimulation with fewer injections. Compare reported weekly use, trial doses, recovery goals and the trade-offs.
CJC-1295 without DAC (Modified GRF 1-29)
CJC-1295 no DAC is sought for better sleep, workout recovery and a leaner physique, often with ipamorelin. Compare reported doses, duration and the daily-use trade-off.
Tesamorelin
Tesamorelin for visceral belly fat: Egrifta doses, how long treatment is studied and what happens after stopping.